Wednesday 26 September 2018

Case Write Up O&G (Diabetes complicationg pregnancy)


Introduction
Mrs H is a 41 years old housewife, G3P2 at 38 weeks of gestation admitted for diabetes complicating pregnancy.

Menstrual History
She attained menarche 15 years old. Her cycle is irregular every 1-2 months lasted for not more than 4 days flow. The amount was about 2-3 pads fully-soaked.
She does not experience dysmenorrhea, menorrhagia, intermenstrual bleeding, dyspareunia or post coital bleeding.
Her first day of menstrual period is 12 or 10/03/2017 (she could not remember).
Her revised expected delivery date (REDD) is 11/12/2017.

History of Present Pregnancy/Antenatal History
This is unplanned pregnancy but welcomed.
She confirmed her pregnancy by doing urine pregnancy test (UPT) at private clinic (Jalan Setapak Family Clinic) after 2 weeks of first day of menstrual period.
She did booking at 24th weeks at KK Gombak Setia with green coded book. The initial baseline was as below:
            Weight : 78 kg
            Height : 153 cm
            BMI : 33.3 kg/m2
                    Blood pressure : Normal (Not sure of exact value)
Blood test was done and the result was as below:
            Hb : Normal (Not sure exact value)
            Blood group : A
            Rh : +
            Infective screening : Non reactive (HIV, VDRL and Hepatitis B)
ATT was given twice. She received one dose when she is in Iran (could not remember when). Another one was given in Malaysia (KK Gombak Setia) because all the antenatal document was left in Iran.
There was no problems in first trimester such as bleeding or anemia.
Quickening felt at 20th weeks.
Modified Glucose Tolerance Test (MGTT) was not done because she is already diabetic.
She compliance to antenatal check up. Scan was done and the pregnancy was viable and in good condition.
There was no problem in second trimester such as anemia, pre-eclampsia or placenta previa.
There was no problem in third trimester such as breech presentation, hypertension or transverse lie.
On 15/09/2017, she received referral letter for further management by MO at KK Gombak Setia due to uncontrolled diabetes mellitus and defaulted check up during antenatal check up.
On 16/09/2017, she warded in ward 2A Bed 5 due to macrosomic fetus. There were no signs of labour like painful uterine contractions, leaking liquor or show. Fetal movement was good and the CTG was reactive. A transabdominal ultrasound was done at the PAC and the estimated fetal weight was 4.2 kg.

Past Obstetric History
Between 2012 to 2016, she has 2 pregnancies. There is no miscarriages. Both of them are boys.
All of them were delivered in Hospital Kuala Lumpur (HKL) and delivered by spontaneous vaginal delivery (SVD).
Both of them were breast fed up to 2 years and had completed immunization. Both children are still alive and healthy. She does not practice any contraception.

No
Year
Place
Mode of delivery
Sex
Weight
Breast fed
Comment
1
2012
HKL
SVD
Male
1.8 kg
2 years
-
2
2013
HKL
SVD
Male
1.4 kg
2 years
Warded 100 days due to lung infection

Past Gynaecology History
She has done pap smear once in Iran in 2015 and the result was normal.
Never undergo operation before such as myomectomy or D&C.
No previous gynaecology history such as fibroid, cyst, pelvic inflammatory disease or endometrioma.

Past Medical History
She has never been warded before due to any medical illness.
She has diabetes mellitus. It was diagnosed accidentally during health checkup in mall in 2010. She has symptoms of numbness at peripheral. She does not take any medication and defaulted treatment and currently on diet control.
Otherwise, she does not have hypertension, renal disease, cardiovascular disease, thyroid disease, epilepsy and asthma.


Past Surgical History
She does not have any surgery or operation before.

Drugs History
She is not on any medications before. She was only on obimin as prescribed by the doctor during pregnancy.
Otherwise, no over the counter and herbal medication.

Allergic History
No allergic history.
Not having allergy to food or medication.

Family History
 
Her father died at age of more than 60 years old due to heart attack. He had diabetes mellitus.
Her mother is still alive currently 68 years old. She has diabetes mellitus, hypertension and heart problem.
The patient has 8 siblings. She is the 7th out of 8.
Her eldest brother passed away due to heart problem and pleural effusion.
There are 3 girls in this family. All of them does not have gynaecology problems such as fibroid or ovarian cysts.
There were no multiple pregnancies, fetal abnormalities or malignancy. Otherwise, all siblings are healthy.

Social History
Patient currently work as housewife. Her husband’s job is businessman. Total family income is about RM10k a month.
Patient is an ex-smoker. She started at age 18 years old. She smoked about 1-2 sticks per day. She stopped in 2012 after knowing she was pregnant.
Patient also is an ex-alcoholic drinker. She drunk occasionally. She started at age of 18 years old. She stopped in 2012 due to same reason.
She live at PPR Setapak with her family. It is flat house with good accommodation utility such as water, electricity and sanitation.
She controls her diet by avoiding excessive food intake and high-cholesterol diet to reduce her body weight as advised by the doctor.

Summary
Mrs H, 41 years old admitted 2 days ago G3P2 (38 weeks) due to diabetes complicating pregnancy for further management.


General Examination
Patient is lying down comfortably with 1 pillow. She is not in distress and well hydrated. She is friendly and cooperative.
Her vitals signs are as follows:
            Blood Pressure – 110/70 mmHg
            Pulse Rate – 72 beats per minute
            Respiratory Rate – 18 breaths per minute
            Temperature – 37 ˚C

Hand             : No clubbing, CRT<2 sec, warm and no palmar erythema
Eyes               : No anemia and no jaundice
Mouth           : Good oral hygiene, good hydration status, no angular stomatitis       
  and central cyanosis.
Thyroid         : Not swell and no jaundice.
Breast            : No nodules or discharge(Patient refused)
Legs                : No edema and varicose vein.

Systemic review
- CVS              : S1 S2 heart sound heard. No murmur.
- RESPI           : air entry is good, vesicular breath sound and no added sound.


Abdominal Examination

Inspection
Abdomen is distended with gravid uterus with evidence of lineanigra. There was no striaegravidarum and no dilated vein.
Umbilicus is flat.
There is no surgical scar, no hernia orifices and skin lesion such as scratches mark.

Palpation
Abdomen is soft and non-tender.
SFH = 33 cm , FH = 34 weeks
There is singleton fetus lying on longitudinal lie, in cephalic presentation.
Estimate fetal weight is 2.5 – 3.0 kg.
Liquor is adequate.
The heart rate most likely is at the right iliac fossa.

Auscultation
The fetal heart sound heard.



Diagnosis

Provisional diagnosis
Diabetes complicating pregnancy

Differential Diagnosis
Gestational Diabetes Mellitus

Investigation

Investigations upon admission to HKL @ 16/09/2017
1.        Transabdominal ultrasound scan on 16/09/2017
                        Estimated birth weight – 4.0 – 4.2 kg
                        Amniotic fluid index was 18

2.        Blood sugar profile

3.        Cardiotocograph
                        Reactive (Fetal not in distress)

4.        Full blood count

Management

1.        Nil by mouth

2.        Continue treatment for GDM before the day before the procedure

3.        Blood sugar profile checked hourly

4.        Plan for Caesarean section


Progress During Hospitalization

Day 1 post operation

The operation was uneventful. Baby born with birth weight of 4.88kg was delivered at 1640H with Apgar score 9 in 1 min and 10 in 10 mins. Estimated blood loss was 500ml. Liquor was clear.

After the operation, she has been keeping well.

BP – 108/70 mmHg

Pulse rate – 70 beats per minute, regular

She was pale but alert, complaining of nausea, no vomiting, no shortness of breath or palpitation. She was strict on pad chart. Since the operation, she has been using 3 pads full-soaked.

On abdomen examination, the uterus was not well-contracted at 22-week size of a gravid uterus

She given IV oxytocin 40 units over 6 hours.

Day 3 post operation

Uterus was soft, non-tender, well-contracted at 20 weeks size of a gravid uterus, no active bleeding at the site of operation. No longer has per vaginal bleeding.

She was due for discharge and was told to repeat modified glucose tolerance test 6 weeks later.


Discussion

This lady is a known case of diabetes mellitus should have been given preconceptional counselling to achieve tight control of diabetes before the onset of pregnancy. Since the patient defaulted treatment and follow up, her blood sugar level was uncontrolled. If she compliance to diabetes follow up, her HbA1c level should be measured to plan pregnancy, taught about self-glucose monitoring and appropriate advice about diet and insulin is given. Aim for HbA1C levels of 6.1 % or less.

During antenatal care, she should be advised about proper diet for stabilization of blood glucose. If values are exceeded even on diet, insulin therapy is suggested. Frequent blood sugar estimation is required as the urine examination of sugar is not informative. Assessment of fetal well-being by sonography is to be made from 28 weeks onwards to check for suspicion of macrosomia.

When diabetes is first detected during pregnancy and cannot be controlled by diet alone, it should be treated with insulin. A postprandial (2 hours) plasma glucose level of more than 140 mg% even on diet control is an indication of insulin therapy. The aim is to maintain the blood sugar levels as near to normal as possible without causing troublesome hypoglycaemia. Since the patient defaulted treatment, her DM cannot be control.

Diabetic women controlled on insulin are considered for induction of labor after 38 completed weeks. But in this patient, her DM is not control , so Caesarean section is best choice of mode of delivery. During 38 weeks, the doctor detected macrosomia by ultrasound in latest antenatal check up. So, she was referred by MO to HKL for Caesarean section. Her estimated baby weight is 4 – 4.5kg (macrosomia) and it is indicated for Caesarean section.

During puerperium, antibiotics should be given prophylactically to minimize infection. Insulin requirement falls dramatically following delivery. She is to revert to the insulin regime. Breastfeeding is encouraged.


References

1.        DC Dutta’s Textbook of Obstetrics 8th edition
2.        Clinical Protocols in Obstetrics and Gynaecology for Malaysian Hospitals.

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